Serveur d'exploration sur les relations entre la France et l'Australie

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Antiviral drug-resistant HBV : Standardization of nomenclature and assays and recommendations for management

Identifieur interne : 009722 ( Main/Exploration ); précédent : 009721; suivant : 009723

Antiviral drug-resistant HBV : Standardization of nomenclature and assays and recommendations for management

Auteurs : Anna S. Lok [États-Unis] ; Fabien Zoulim [France] ; Stephen Locarnini [Australie] ; Angeline Bartholomeusz [Australie] ; Marc G. Ghany [États-Unis] ; Jean-Michel Pawlotsky [France] ; Yun-Fan Liaw [Taïwan] ; Masashi Mizokami [Japon] ; Carla Kuiken [États-Unis]

Source :

RBID : Pascal:07-0342113

Descripteurs français

English descriptors

Abstract

Substantial advances have been made in the treatment of chronic hepatitis B in the past decade. Approved treatments for chronic hepatitis B include 2 formulations of interferon and 4 nucleos(t)ide analogues (NAs). Sustained viral suppression is rarely achieved after withdrawal of a 48-week course of NA therapy, necessitating long, and in many cases, indefinite treatment with increasing risk of development of drug resistance. Antiviral resistance and poor adherence are the most important factors in treatment failure of hepatitis B. Thus, there is a need to standardize nomenclature relating to hepatitis B antiviral resistance, and to define genotypic, phenotypic, and clinical resistance to NA therapy.


Affiliations:


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Le document en format XML

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<country>États-Unis</country>
<wicri:noRegion>Ann Arbor, MI</wicri:noRegion>
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<country>France</country>
<placeName>
<region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
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<name sortKey="Locarnini, Stephen" sort="Locarnini, Stephen" uniqKey="Locarnini S" first="Stephen" last="Locarnini">Stephen Locarnini</name>
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<s1>Victorian Infectious Diseases Reference Laboratory</s1>
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<name sortKey="Bartholomeusz, Angeline" sort="Bartholomeusz, Angeline" uniqKey="Bartholomeusz A" first="Angeline" last="Bartholomeusz">Angeline Bartholomeusz</name>
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<s1>Victorian Infectious Diseases Reference Laboratory</s1>
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<name sortKey="Ghany, Marc G" sort="Ghany, Marc G" uniqKey="Ghany M" first="Marc G." last="Ghany">Marc G. Ghany</name>
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<wicri:noRegion>Bethesda, MD</wicri:noRegion>
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<name sortKey="Pawlotsky, Jean Michel" sort="Pawlotsky, Jean Michel" uniqKey="Pawlotsky J" first="Jean-Michel" last="Pawlotsky">Jean-Michel Pawlotsky</name>
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<s1>French National Reference Center for Viral Hepatitis B, C and delta, Department of Virology and INSERM U841, Hopital Henri Mondor, Universite Paris 12</s1>
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<name sortKey="Liaw, Yun Fan" sort="Liaw, Yun Fan" uniqKey="Liaw Y" first="Yun-Fan" last="Liaw">Yun-Fan Liaw</name>
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<s1>Liver Research Unit, Chang Gung University and Memorial Hospital</s1>
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<country>Taïwan</country>
<wicri:noRegion>Taipei</wicri:noRegion>
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<name sortKey="Mizokami, Masashi" sort="Mizokami, Masashi" uniqKey="Mizokami M" first="Masashi" last="Mizokami">Masashi Mizokami</name>
<affiliation wicri:level="1">
<inist:fA14 i1="07">
<s1>Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences</s1>
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<country>Japon</country>
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<name sortKey="Kuiken, Carla" sort="Kuiken, Carla" uniqKey="Kuiken C" first="Carla" last="Kuiken">Carla Kuiken</name>
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<s1>Theoretical Biology and Biophysics Group (T-10), Los Alamos National Laboratory</s1>
<s2>Los Alamos, NM</s2>
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<sZ>9 aut.</sZ>
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<country>France</country>
<placeName>
<region type="region">Auvergne-Rhône-Alpes</region>
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<name sortKey="Bartholomeusz, Angeline" sort="Bartholomeusz, Angeline" uniqKey="Bartholomeusz A" first="Angeline" last="Bartholomeusz">Angeline Bartholomeusz</name>
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<name sortKey="Ghany, Marc G" sort="Ghany, Marc G" uniqKey="Ghany M" first="Marc G." last="Ghany">Marc G. Ghany</name>
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<s1>Liver Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health</s1>
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<country>États-Unis</country>
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<name sortKey="Pawlotsky, Jean Michel" sort="Pawlotsky, Jean Michel" uniqKey="Pawlotsky J" first="Jean-Michel" last="Pawlotsky">Jean-Michel Pawlotsky</name>
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<country>France</country>
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<region type="region">Île-de-France</region>
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<name sortKey="Liaw, Yun Fan" sort="Liaw, Yun Fan" uniqKey="Liaw Y" first="Yun-Fan" last="Liaw">Yun-Fan Liaw</name>
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<s1>Liver Research Unit, Chang Gung University and Memorial Hospital</s1>
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<s3>TWN</s3>
<sZ>7 aut.</sZ>
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<country>Taïwan</country>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mizokami, Masashi" sort="Mizokami, Masashi" uniqKey="Mizokami M" first="Masashi" last="Mizokami">Masashi Mizokami</name>
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<s1>Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences</s1>
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<sZ>8 aut.</sZ>
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<country>Japon</country>
<wicri:noRegion>Nagoya</wicri:noRegion>
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<name sortKey="Kuiken, Carla" sort="Kuiken, Carla" uniqKey="Kuiken C" first="Carla" last="Kuiken">Carla Kuiken</name>
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<title level="j" type="main">Hepatology : (Baltimore, Md.)</title>
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<term>Antiviral</term>
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<term>Recommendation</term>
<term>Standardization</term>
<term>Treatment</term>
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<term>Hépatite virale B</term>
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<div type="abstract" xml:lang="en">Substantial advances have been made in the treatment of chronic hepatitis B in the past decade. Approved treatments for chronic hepatitis B include 2 formulations of interferon and 4 nucleos(t)ide analogues (NAs). Sustained viral suppression is rarely achieved after withdrawal of a 48-week course of NA therapy, necessitating long, and in many cases, indefinite treatment with increasing risk of development of drug resistance. Antiviral resistance and poor adherence are the most important factors in treatment failure of hepatitis B. Thus, there is a need to standardize nomenclature relating to hepatitis B antiviral resistance, and to define genotypic, phenotypic, and clinical resistance to NA therapy.</div>
</front>
</TEI>
<affiliations>
<list>
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<li>Australie</li>
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<name sortKey="Ghany, Marc G" sort="Ghany, Marc G" uniqKey="Ghany M" first="Marc G." last="Ghany">Marc G. Ghany</name>
<name sortKey="Kuiken, Carla" sort="Kuiken, Carla" uniqKey="Kuiken C" first="Carla" last="Kuiken">Carla Kuiken</name>
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<name sortKey="Zoulim, Fabien" sort="Zoulim, Fabien" uniqKey="Zoulim F" first="Fabien" last="Zoulim">Fabien Zoulim</name>
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<name sortKey="Pawlotsky, Jean Michel" sort="Pawlotsky, Jean Michel" uniqKey="Pawlotsky J" first="Jean-Michel" last="Pawlotsky">Jean-Michel Pawlotsky</name>
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<country name="Australie">
<noRegion>
<name sortKey="Locarnini, Stephen" sort="Locarnini, Stephen" uniqKey="Locarnini S" first="Stephen" last="Locarnini">Stephen Locarnini</name>
</noRegion>
<name sortKey="Bartholomeusz, Angeline" sort="Bartholomeusz, Angeline" uniqKey="Bartholomeusz A" first="Angeline" last="Bartholomeusz">Angeline Bartholomeusz</name>
</country>
<country name="Taïwan">
<noRegion>
<name sortKey="Liaw, Yun Fan" sort="Liaw, Yun Fan" uniqKey="Liaw Y" first="Yun-Fan" last="Liaw">Yun-Fan Liaw</name>
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</country>
<country name="Japon">
<noRegion>
<name sortKey="Mizokami, Masashi" sort="Mizokami, Masashi" uniqKey="Mizokami M" first="Masashi" last="Mizokami">Masashi Mizokami</name>
</noRegion>
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